VYVGART is a neonatal Fc receptor blocker indicated for the treatment of generalized myasthenia gravis (gMG) in adult patients who are anti-acetylcholine receptor (AChR) antibody positive.
It is an IV infusion once weekly for 4 weeks. It is given over 1 hour with a 1 hour observation period after the infusion.
The most common adverse reactions (≥ 10%) in patients treated with gMG are: respiratory tract infections, headache, and urinary tract infection.
In clinical trials, participants achieved significant improvements with daily activities (68% of patients) and a reduction in muscle weakness (63% of patients) when Vyvgart was added to current gMG treatment.
Vyvgart is an intravenous infusion administered over 1 hour every week for 4 weeks (4 infusions total). Vyvgart is given in treatment cycles with a break in between each cycle. Your neurologist will determine the timing of the next treatment cycle based on your symptoms and any side effects after treatment.
The average time between treatment cycles is 94 days.
The most common side effects of Vyvgart include respiratory tract infections, headache, and urinary tract infections.
Vyvgart can cause serious side effects including hypersensitivity reactions such as a rash, shortness of breath, and/or angioedema. You will be monitored during your infusion and for at least 1 hour following each infusion for signs and symptoms of a hypersensitivity reaction.
Advise your doctor that you will need to complete all age-appropriate vaccinations according to immunization guidelines prior to initiation of a new treatment cycle with Vyvgart. Immunization with live-attenuated or live vaccines is not recommended during treatment with Vyvgart due to a possible transient reduction in IgG levels.
Vyvgart may increase the risk of infection. It is important to contact your healthcare provider if you develop any symptoms that may be related to an infection.
For a full list of potential side effects, please see the Important Safety Information and Medication Guide on the VYVGART website.
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